Markus Heilig Selected Research

Excitatory Amino Acid Transporter 1 (Glutamate Aspartate Transporter 1)

5/2009	Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia.
11/2008	Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist.

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Markus Heilig Research Topics

Disease

64	Alcoholism (Alcohol Abuse) 01/2022 - 01/2002
7	Substance-Related Disorders (Drug Abuse) 01/2021 - 10/2002
6	Heroin Dependence (Heroin Abuse) 03/2015 - 01/2002
5	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022 - 01/2015
4	Opioid-Related Disorders (Opiate Addiction) 10/2021 - 02/2003
4	Mental Disorders (Mental Disorder) 01/2021 - 11/2016
3	Substance Withdrawal Syndrome (Withdrawal Symptoms) 12/2019 - 10/2014
3	Insulin Resistance 12/2016 - 04/2011
2	Inflammation (Inflammations) 01/2021 - 05/2014
2	Nausea 01/2017 - 01/2015
2	Type 2 Diabetes Mellitus (MODY) 08/2013 - 04/2011
2	Anxiety Disorders (Anxiety Disorder) 02/2012 - 11/2003
2	Body Weight (Weight, Body) 07/2009 - 03/2007
2	Schizophrenia (Dementia Praecox) 05/2009 - 11/2008
2	Depressive Disorder (Melancholia) 10/2006 - 10/2002
1	Autism Spectrum Disorder 04/2022
1	Anhedonia 01/2021
1	Muscular Diseases (Myopathy) 08/2020
1	Major Depressive Disorder (Major Depressive Disorders) 01/2019
1	Pain (Aches) 01/2018
1	Wounds and Injuries (Trauma) 03/2017
1	Vomiting 01/2017
1	Hypersensitivity (Allergy) 05/2013

Drug/Important Bio-Agent (IBA)

8	Pharmaceutical PreparationsIBA 01/2021 - 10/2002
7	Buprenorphine (Subutex)FDA LinkGeneric 04/2022 - 02/2003
6	Opioid Analgesics (Opioids)IBA 04/2022 - 10/2011
6	Biomarkers (Surrogate Marker)IBA 08/2020 - 03/2005
6	Naltrexone (ReVia)FDA LinkGeneric 01/2017 - 01/2002
5	Pioglitazone (Actos)FDA Link 08/2020 - 04/2011
5	Ethanol (Ethyl Alcohol)IBA 01/2018 - 03/2007
5	Biological ProductsIBA 01/2016 - 01/2008
5	Acamprosate (Campral)FDA Link 03/2014 - 01/2002
5	Corticotropin-Releasing HormoneIBA 04/2013 - 10/2006
4	Glutamic Acid (Glutamate)FDA Link 01/2016 - 11/2008
4	Methadone (Dolophine)FDA LinkGeneric 07/2008 - 02/2003
4	Neuropeptide YIBA 05/2005 - 01/2002
3	EndocannabinoidsIBA 01/2022 - 01/2002
3	EnzymesIBA 01/2021 - 05/2014
3	gamma-Aminobutyric Acid (GABA)IBA 01/2018 - 10/2011
3	NociceptinIBA 10/2016 - 11/2009
3	NeuropeptidesIBA 11/2015 - 11/2003
3	mu Opioid Receptors (mu Opioid Receptor)IBA 05/2015 - 02/2005
3	Serotonin (5 Hydroxytryptamine)IBA 10/2011 - 09/2004
2	salicylhydroxamic acid (SHAM)IBA 01/2022 - 01/2020
2	ElementsIBA 08/2021 - 08/2007
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 04/2015
2	CytokinesIBA 01/2021 - 10/2018
2	Nicotine FDA Link 10/2020 - 12/2019
2	fatty-acid amide hydrolase (fatty acid amide hydrolase)IBA 01/2020 - 11/2016
2	Dopamine (Intropin)FDA LinkGeneric 01/2018 - 12/2005
2	Hypnotics and Sedatives (Sedatives)IBA 01/2018 - 03/2008
2	Opioid Receptors (Opioid Receptor)IBA 01/2018 - 02/2003
2	Aprepitant (Emend)FDA Link 01/2017 - 01/2015
2	Heroin (Diamorphine)IBA 03/2015 - 01/2008
2	pexacerfontIBA 03/2015 - 03/2013
2	CRF receptor type 1IBA 03/2015 - 03/2007
2	Adrenocorticotropic Hormone (ACTH)FDA Link 03/2015 - 11/2009
2	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 04/2013 - 03/2008
2	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)IBA 04/2013 - 03/2012
2	Nociceptin ReceptorIBA 11/2009 - 03/2008
2	Haloperidol (Haldol)FDA LinkGeneric 05/2009 - 11/2008
2	LY 379268IBA 05/2009 - 11/2008
2	Excitatory Amino Acid Transporter 1 (Glutamate Aspartate Transporter 1)IBA 05/2009 - 11/2008
2	Aspartic Acid (Aspartate)FDA Link 05/2009 - 11/2008
2	Narcotic Antagonists (Opioid Antagonists)IBA 09/2006 - 02/2005
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Histone DemethylasesIBA 01/2021
1	Histones (Histone)IBA 01/2021
1	Cyclooxygenase 1IBA 01/2021
1	ProstaglandinsIBA 01/2021
1	Baclofen FDA LinkGeneric 01/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021
1	PPAR gammaIBA 08/2020
1	PF-5190457IBA 01/2020
1	Opiate AlkaloidsIBA 10/2018
1	1-phosphatidylinositol-4-phosphate 5-kinaseIBA 01/2018
1	Analgesics (Analgesic Drugs)IBA 01/2018
1	ThiazolidinedionesIBA 12/2016
1	Rosiglitazone (Avandia)FDA Link 12/2016
1	Varenicline (Chantix)FDA Link 07/2015
1	MethyltransferasesIBA 04/2015
1	Glucose (Dextrose)FDA LinkGeneric 03/2015
1	Neurokinin-1 Receptor AntagonistsIBA 01/2015
1	2- (3- (1- (acenaphthen- 1- yl)piperidin- 4- yl)- 2- oxo- 2,3- dihydro- 1H- benzimidazol- 1- yl)- N- methylacetamideIBA 10/2014
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 05/2014
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2013
1	N- ((2- cyclopropoxy- 5- (5- trifluomethyl)tetrazol- 1- yl)benzyl)- 2- phenylpiperidin- 3- amineIBA 05/2013
1	Antidepressive Agents (Antidepressants)IBA 03/2013
1	Anti-Anxiety Agents (Anxiolytics)IBA 03/2013
1	metabotropic glutamate receptor 2IBA 02/2013
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 02/2012
1	Monoamine Oxidase (MAO)IBA 02/2012
1	Proteins (Proteins, Gene)FDA Link 02/2012

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 01/2018 - 11/2003
8	Therapeutics 01/2020 - 02/2003
3	Transcranial Magnetic Stimulation 01/2022 - 01/2019
2	Self Administration (Administration, Self) 01/2017 - 03/2015
2	Precision Medicine 05/2015 - 03/2013
2	Self Medication 04/2010 - 10/2002
1	Psychotherapy Imagery (Guided Imagery) 07/2015